# Chuck Manski

Type: Person

Source: Biotech Intelligence Brief — https://getbiobrief.com/entity/chuck-manski
Canonical HTML page: https://getbiobrief.com/entity/chuck-manski

## Recent coverage (1 stories)

### Opdivo's 1/12th Dose Shows Efficacy in Indian Study, Sparking FDA Label Debate
2026-08-20 09:12:41 · Sentiment: Negative · Impact: 7/10 · Sources: 2

Biopharma companies face a growing dose-optimization debate as researchers present evidence that checkpoint inhibitors such as Opdivo and Keytruda can be effective at fractions of FDA-approved doses. Regulatory and commercial models built on fixed dosing face pressure to incorporate dose-ranging data.
Full story: https://getbiobrief.com/story/biotech-cancer-drug-dosing-challenge-keytruda-opdivo

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